Pitt vs. Iowa State odds, picks and predictions

The Pitt Panthers will look to extend their winning streak when they face the Iowa State Cyclones in a marquee Big 12 matchup. With the Panthers favored by 4.5 points and the over/under set at 56.5, the sportsbooks are expecting a close game. The Cyclones are coming off a season-opening loss to the Louisiana Ragin’ Cajuns, while the Panthers have earned two straight wins over the Virginia Tech Hokies and the Louisville Cardinals.

For Pitt, the focus will be on quarterback Kenny Pickett, who has been impressive in his first two starts of the season. He’s completed 64.3 percent of his passes for 394 yards and four touchdowns against just one interception. Pickett has also shown the ability to make plays with his legs, rushing for 73 yards and two touchdowns.

Iowa State will counter with their own dynamic duo in quarterback Brock Purdy and running back Breece Hall. Purdy completed 22-of-33 passes for 230 yards and one touchdown in the Cyclones’ loss to Louisiana. Hall has also been impressive, averaging 5.9 yards per carry for 100 yards in the season opener.

Pitt is a 4.5-point favorite despite the talent on Iowa State’s roster, and the Panthers have the edge in the trenches. Pitt has held its own on the defensive side of the ball this season, allowing just 21.5 points per game. Meanwhile, the Cyclones have struggled to contain opposing offenses, giving up 31 points to Louisiana in the season opener.

The Panthers’ offense likely has the edge over the Cyclones’ defense as well. Pickett has been efficient and mistake-free so far, while Iowa State’s defense has been vulnerable to big plays. With Pitt’s running game revving up, the Panthers should be able to move the ball consistently against Iowa State’s defense.

The Panthers are the clear favorite in this matchup, and the oddsmakers are expecting a close game. A Pitt win is the most likely outcome, but the Cyclones have plenty of talent to keep the game competitive. For those looking to make a bet, the Panthers are the pick to cover the 4.5-point spread.